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Semaglutide works through several mechanisms: it slows gastric emptying (the rate at which food leaves your stomach), increases feelings of fullness, reduces appetite signals in the brain, and improves insulin secretion whilst suppressing glucagon release

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Tesamorelin is a synthetic 44-amino-acid GHRH analog with a trans-3-hexenoic acid modification at the N-terminus and an extended plasma half-life, FDA-approved as Egrifta for visceral adipose tissue reduction in HIV-associated lipodystrophy

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But three injections per week starts to feel burdensome for many people, and the incremental benefit over twice-weekly dosing may not justify the additional injections

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