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Most people see initial effects within two to four weeks, but maximum benefit requires months of consistent use

Recent systemic review and meta-analysis demonstrated, that treatment with functional agonists of GLP-1 which included both GLP-1RAs and DPP4 inhibitors resulted in a significant reduction of depression rating scores and tended to be superior over control treatments, which supports the hypothesis of their antidepressant action in humans

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Participants who switched from tirzepatide to placebo after 36 weeks of treatment regained substantial weight, while those who continued tirzepatide maintained their weight loss and continued losing

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