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Selenium supplementation (if dietary intake is inadequate) supports glutathione enzyme function

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In certain embodiments, tonicity agents are added to the formulations described herein in an amount as to provide a practical osmolality of an otic formulation of about 100 mOsm/kg to about 1000 mOsm/kg, from about 200 mOsm/kg to about 800 mOsm/kg, from about 250 mOsm/kg to about 500 mOsm/kg, from about 250 mOsm/kg to about 350 mOsm/kg, or from about 280 mOsm/kg to about 320 mOsm/kg

doi: 10.1021/acs.nanolett.0c03279 258 ZhaiK-FDuanHKhanGJXuHHanF-KCaoW-Get al