A practical heuristic: if youre set on using a modified form, the more conservative middle-ground protocols (1 mg/day for 20 days for N-acetyl amidate, or 1-2 mg for amidate alone) sit closer to the dose math that would be theoretically equivalent to the base epithalon protocols if the modifications deliver something like 5-10x bioavailability improvement
AHK-Cu has been studied extensively in animal and laboratory models by the cosmeceutical industry for its effects on skin health, collagen synthesis, and hair growth
5-Amino-1MQ is frequently referenced in research literature examining NNMT-associated biochemistry under controlled laboratory conditions
Wallace E
PubMed DOI Seiwerth S, Brcic L, Vuletic LB, et al
Furthermore, prior to division, Drp1, Mff, and MiD49/51 bind specifically to endoplasmic reticulum-mitochondrial contact sites, where they facilitate mitochondrial membrane remodeling and division (Osellame et al., 2016