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Published data shows secretagogues have a milder side effect profile

Most vitamins and supplements absorb well and feel gentler on your stomach when paired with a meal or snack

In the other case (labeled as sub-optimal), behavioral and emotional effects have limited treatment to a sub-therapeutic amitriptyline level associated with only partial efficacy

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The authors attribute this observation to the young age of the study patients, many of whom were preadolescent and thus had not experienced prominent hormone changes