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Insulin exerts a synergistic effect with gonadotropins on both granulosa and theca cells: hyperinsulinemia amplifies luteinizing hormone (LH) signaling and upregulates the expression of steroidogenic enzymes, thereby promoting ovarian and adrenal androgen synthesis

57,69,78,94,296 The ONATA study showed a negative correlation between serum uric acid levels and insulin sensitivity, suggesting a potential link between uric acid, insulin sensitivity, and the risk of developing hypertension

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Hormone therapy helps with weight loss, energy, muscle building, and overall stamina