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One concern noted in legal documents is that original labels lacked warnings of serious side effects, including severe gastrointestinal issues and other dangerous conditions

A study investigating teat-end hyperkeratosis in commercial dairy herds found no significant association between hyperkeratosis and mastitis-causing pathogens 191

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The SURMOUNT-4 randomized clinical trial assessed the effect of tirzepatide discontinuation on the maintenance of weight reduction in adults with obesity and a weight-related complication, excluding diabetes

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