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Efficacy and safety of tirzepatide monotherapy compared with dulaglutide in Japanese patients with type 2 diabetes (SURPASS J-mono): a double-blind, multicentre, randomised, phase 3 trial

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Reason for caution: GLP-1 therapy can improve insulin sensitivity and secretion in a way that, combined with other glucose-lowering drugs, can push blood sugar too low

Additionally, a 2018 study suggested potential pancreatic cancer protection in individuals with type 2 diabetes who used incretin-based therapies over an extended period

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