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GLP-1 receptor agonists Primary mechanism(s) of action Increase glucose-dependent insulin secretion, reduce post-prandial glucagon, and delay gastric emptying (resulting in reduced after meal glucose levels and increased satiety) Examples Exenatide (Byetta 10 mcg Pen, Byetta 5 mcg Pen, Bydureon BCise 2 mcg Pen) Dosage Immediate release (Byetta) Initial: 5 mcg subcutaneous injection twice daily a maximum of 60 minutes before morning and evening meals, or before the two main meals of the day Maximum: 10 mcg subcutaneous injection twice daily a maximum of 60 minutes before morning and evening meals, or before the two main meals of the day Extended release (Bydureon BCise) Initial: 2 mg subcutaneous injection once weekly Maximum: 2 mg subcutaneous injection weekly Lixisenatide (Adlyxin) Short-acting Dosage Initial: 10 mcg subcutaneous injection once daily, up to one hour before the first meal of the day, for 14 days

Key Takeaways Peptides act as targeted messengers for your brain : They work on a cellular level to protect neurons, balance key brain chemicals, and strengthen the pathways responsible for memory and clear thinking

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Comparative Studies of CagriSema Comparative studies of CagriSema have shown that it results in significantly more weight loss than either cagrilintide or semaglutide alone

Sadeghi et al., 2022)

It is also helpful for people with chronic muscle tension or joint discomfort