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This underscores the importance of addressing the root causes of weight gain through sustainable lifestyle changes, such as: Long-term dietary changes focusing on a lower-glycemic diet with sufficient protein Building a consistent exercise routine Mindful eating practices to retrain hunger cues Emotional and behavioral factors For many, overeating or obesity has emotional and psychological roots

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In serum starvation-induced HO-23 cells, DHEA was found to reduce the expression of necroptosis markers RIPK1 and RIPK3 (Tsui et al., 2017)

Excessive muscle loss can therefore make long-term weight maintenance more challenging

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