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Translational and Clinical Implications The convergence of circadian biology, sleep physiology, and GLP-1 receptor agonist therapy carries important implications for both research and clinical practice

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Based on recent anecdotal reports, there are concerns that delayed gastric emptying from GLP-1 agonists can increase the risk of regurgitation and pulmonary aspiration of gastric contents during general anesthesia and deep sedation

Intranasal bioavailability is estimated at 60-70%, with onset of anxiolytic effects within 5-15 minutes

So there could be consequences that we do not even realize right now, Gler said