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Glucose intolerance and, rarely, benign intracranial hypertension have also been reported

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Perturbations in their function reshape the dynamics of secondary messengers including Ca 2 , ROS, nitric oxide, and phospholipidslinking perception to downstream signaling (Sies and Jones 2020

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Examples include intractable vomiting causing dehydration, severe abdominal pain, or persistent symptoms that do not respond to conservative management