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Curcumin can activate Nrf2 signaling pathway via inhibiting Keap1, upregulating Nrf2 and inducing the nuclear translocation of Nrf2 (Ashrafizadeh et al., 2020)
Beyond improving sleep quality, DSIP has been studied for its potential to regulate stress responses, balance hormonal activity, and support recovery in both the nervous and endocrine systems
Any future oral formulation would likely share similar systemic effects, though the gastrointestinal profile might differ
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