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Replicative endothelial cell senescence may lead to endothelial dysfunction by increasing the BH2/BH4 ratio induced by oxidative stress, reducing BH4 availability, and decreasing the expression of eNOS

doi: 10.1016/j.ygcen.2012.07.028 131 YangBJiangQChanTKoWKWWongAOL

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So it's important that we address what we actually know and what we don't know, and we'll do that in a second