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This 28day guideline comes from the USP Compounding Standards, which sets standards for sterile compounding and states that an opened multidose vial with antimicrobial preservative should be discarded within 28 days unless the manufacturer specifies otherwise

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2 In the REIMAGINE 3 trial, the most commonly reported AEs were GI-related, occurring in 51/90 (57%) participants in the CagriSema 2.4 mg/2.4 mg group, 42/93 (45%) participants in the CagriSema 1 mg/1 mg group, and 21/91 (23%) participants in the placebo group