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To determine the specific location of the gastrointestinal (GI) tract where metformin regulates glucose metabolism, the entire GI tract of mice was subjected to autoradiography using 18 F-FDG as a glucose tracer

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5-Aminoimidazole-4-carboxamide-1--D-ribofuranoside (AICAR) effect on glucose production, but not energy metabolism, is independent of hepatic AMPK in vivo

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