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(PubMed) Miller ER, 3 rd , Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E

Women using tirzepatide with oral contraceptives should use non-oral contraception or add a barrier method for 4 weeks after initiation and after each dose increase

This includes: While ongoing research is exploring the long-term effects of semaglutide, its important to monitor your health and consult with your healthcare provider regularly

Clinical research on the FDA-approved branded versions of these active ingredients includes the STEP-1 trial, which demonstrated mean weight reduction of approximately 14.9% with semaglutide over 68 weeks, and the SURMOUNT-1 trial, which showed tirzepatide achieving 1622.5% weight reduction over 72 weeks

Semaglutide is not habit-forming and does not create the euphoria or cravings associated with addiction

Sermorelins pituitary-signaling behavior is discussed in more detail in our reference on how sermorelin affects pituitary signaling in endocrine research