The observation that higher plasma concentrations of 2 can be achieved after oral delivery than for PZQ, coupled with the greater ex vivo potency of compound 2 , strongly suggest that further optimization will yield an orally bioavailable schistosomicidal agent that will be transformative in the clinical setting
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Diab Croat 34:2128 Reznick AZ, Packer L (1994) Oxidative damage to proteins: spectrophotometric method for carbonyl assay
Transcriptomic analysis and qRT-PCR experiments revealed that their combination regulated AD-related pathways and genes more comprehensively, particularly affecting the Neuroactive ligand-receptor interaction and Calcium signaling pathway
Energy production shifts toward glucose and amino acid metabolism instead, which has significant implications for both energy levels and muscle preservation