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GLP-1 drugs lower inflammation across the body in several different ways, which is a big part of why researchers are studying whether they might improve longevity, or prevent cognitive decline, as well as improve conditions like fatty liver disease, and prevent more heart attacks

In its resting state, AhR forms a complex with heat shock protein 90 (HSP90), X-associated protein 2 (XAP2), and p23, localized in the cytoplasm

Semaglutide targets one pathway, while retatrutide is designed to hit three GLP-1, GIP, and glucagon which may explain the stronger weight loss seen in early trials

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One study suggests that Glutathione is linked to better outcomes for COVID-19 patients

Nielsen FH, Johnson LK, Zeng H