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When melanin is overproduced or unevenly distributed, visible darkened areas can develop, presenting as hyperpigmentation or patchy tone

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As the mission duration for astronauts has increased over the past decades, SANS is becoming increasingly recognised, most prominently noted during 6 to 12-month missions onboard the International Space Station (ISS) [1]

When you first take it out of the fridge, note that date on the pen or vial, or keep a note on your calendar to keep track of how many days it's been unrefrigerated

Iranian Journal of Reproductive Medicine, 11 (5), 415