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American Journal of Gastroenterology, 97(2), 213217

Despite limited clinical evidence exists regarding the comprehensive cardiovascular impacts of concurrent treatment with these agents in patients with T2D 18,19,20 , and preclinical studies suggest potential synergistic effects for MASLD 17 , there is a critical need for robust clinical research to evaluate the effect of combined SGLT2is and GLP-1RAs in patients with MASLD

To put that in real numbers: A 150 lb person (68 kg) needs roughly 82 to 109 grams of protein per day A 180 lb person (82 kg) needs roughly 98 to 131 grams of protein per day A 200 lb person (91 kg) needs roughly 109 to 145 grams of protein per day The obvious challenge on GLP-1 is how to hit those numbers when eating 800 to 1200 total calories some days already feels like a stretch

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Stimulant medications like methylphenidate and amphetamines work by increasing dopamine and norepinephrine in the brain, while semaglutide acts on GLP-1 receptors in the gut and brain to regulate appetite and glucose metabolism