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Additionally, mechanical injuries, such as joint wear, trigger inflammatory responses in cartilage and synovium, further upregulating the expression of matrix-degrading proteins, accelerating ECM degradation, and promoting OA progression (Maldonado and Nam, 2013)

The p53 protein itself acts as an intrinsic regulator within the cell, primarily tasked with overseeing the cell cycle's progression, including the initiation of cell death

Articles Submited: September 24, 2018 Published: August 16, 2018 Abstract Background and objectives: The oxidative stress and inflammatory process are cooperative events involved in the development of essential hypertension

The return on investment of pharmaceutical companies for new antibiotics is too low compared to the more profitable drugs for chronic diseases [273]

Each sample was then frozen and dried under vacuum