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This distinguishes it from full-length GH and means that at research-relevant concentrations, the fragment does not produce the insulin resistance, glucose dysregulation, or tissue proliferation associated with GHR-mediated GH signalling allowing isolated study of the GH lipolytic mechanism without these confounding effects

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Without converting based on concentration, dosing errors can occur

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Observational and review-level evidence indicates that patients receiving GLP-1RAs may exhibit micronutrient insufficiencies and lean mass reduction, particularly in vulnerable populations or during prolonged therapy [94, 101]