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Similarly, NAD + levels appear reduced in preclinical models of age-associated diseases, including ataxia-telangiectasia (A-T), mitochondrial myopathies, and Alzheimers disease (AD), and disease-matched clinical samples 114,242,243,244,245,246

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Although some guidelines support treating asymptomatic hyperuricemia to mitigate hypertension, CKD, and CAD risks, treatment initiation requires individual risk stratification pending further validation of cardiovascular/renal benefits (Waheed et al., 2021

Table 2 Alterations in CSF neuropeptide levels in PD patients compared with controls

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