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Mechanistically, semaglutide was found to enhance autophagy, as indicated by increased expression of autophagy-related proteins such as LC3-II, Atg7, and Beclin-1, and decreased expression of p62

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Paschalis, Vassilis, et al

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However, researchers note that the weight loss itself, not direct drug toxicity, is the most likely mechanism

This further inhibits the excessive activation of inflammatory pathways such as the NLRP3 inflammasome and cGASSTING pathway, while maintaining the homeostasis of ATP synthesis in cells, alleviating cell apoptosis and tissue damage, and playing a key protective role in the early compensatory stage of diseases such as heart failure and atherosclerosis