145 Rosmarinic acid demonstrates a hepatoprotective role through inhibition of Nrf2-mediated downregulation of the NIMA (never in mitosis gene a)-related kinase 7-NLRP3 pathway
Vitamin E was administered at 60, 200, or 800 IU for 4 months
suggests that increasing glutathione status can improve the bioavailability of vitamin D and can more effectively correct vitamin D deficiency than vitamin D supplementation alone
Hotchkiss et al., 2009
HT interacts with the downstream target genes of Nrf2, NQO1, and TXNRD1, showing binding energies of 7.8 kcal/mol and 8.9 kcal/mol
6.3 Limitations of novel delivery systems Although recent studies have reported substantial improvements in the delivery efficiency and therapeutic performance of flavonoids using advanced delivery systems, including enhanced stability, bioavailability, and targeting efficiency ( For topical administration routes, including dermal and ocular delivery, hydrogels and nanogels are often limited by suboptimal skin permeability, poor adhesiveness, and challenges in large-scale manufacturing (Grillo et al., 2019
