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GLP-1 itself is a hormone secreted by the intestines in response to food intake, which interacts with receptors in the brain to signal satiety and reduce appetite

For example, in laboratory studies, ovariectomized female rats increase their food intake

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Support for clinical significance came from a responder analysis based on an anchored assessment, which evaluated participants perception of benefit

doi: 10.37212/jcnos.806797 113