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Hydration Awareness: GLP-1s suppress thirst

Abstract The development of osteoarthritis (OA) correlates with the expansion of senescent cells in cartilage, which contributes to an inflammatory microenvironment that accelerates matrix degradation and hampers cartilage generation

The main responsible mechanism is related to autoantibodies that bind and activate the thyrotropin receptor (TSHR)

Whereas chronic exposure specifically inhibits palmitoyl-CoA-dependent -oxidation, creating a dual blockade of substrate utilization that induces energy imbalance (Makrecka-Kuka et al., 2017)

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doi:10.1093/ajcn/nqaa332