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"You don't know if you have the placebo or not, so once I started seeing the results no one ever told me anything different but I saw the results for myself and so I was really surprised." (Jessie wasn't told that the trial was studying retatrutide only that it was a study on a weight loss drug but the research facility confirmed with NBC News.) She's gained back about 15 pounds in the nine months since she completed the trial, but said she still thinks the weight loss is sustainable with healthy lifestyle choices

Cellular Signaling Networks: Investigating complex receptor-mediated pathways