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Additionally, caloric restriction itself may contribute to cold sensitivity

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Appetite and weight changes drive many lab moves, with 75% of patients reporting decreased appetite and clinical trials showing an average 10% body weight reduction over 68 weeks, which explains the typical improvements in glucose and lipid levels

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Trials are studying effects on weight, glucose markers, and broader cardiometabolic outcomes

Laboratory investigations commonly utilize IGF-1 LR3 to examine cellular proliferation mechanisms, metabolic pathway modulation, and protein synthesis regulation in various cell culture systems