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After the Au nanozymes were injected into mice, the surface modification was cut off by matrix metalloproteinase-9 (MMP-9) at the tumor site, releasing free Au particles small enough to be excreted by the kidneys

10.1038/ng.485 184 SauerH.OertelW

Liver fibrosis Chronic injury occurs in alcoholic liver disease, nonalcoholic steatohepatitis, and chronic hepatitis B and C virus infections, ultimately leading to hepatic fibrosis [187]

Thus, there are pronounced interactive effects with classic risk factors, suggesting that homocysteine might further increase the cardiovascular risk in patients bearing these risk factors