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After the discoveries of the gastrointestinal hormones, secretin in 1902 and gastrin in 1905, there was a time when diabetes was treated by injecting intestinal extract, assuming that gastrointestinal hormones were involved in glycemic control of the pancreas [2]

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This information complements clinical assessment to support more informed titration decisions

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Instead, they rely on non-specific activation: caffeine stimulates the central nervous system broadly (affecting attention, energy, and appetite mildly)

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