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Lipid radicals bind with oxygen (O 2 ) to produce a lipid peroxyl radical (LOO), which yields hydrogen from adjacent PUFA to form lipid hydroperoxides (LOOH) and a lipid radical and simultaneously initiate a new lipid radical chain reaction ( Lipoxygenases (LOXs) are considered one of the central players in ferroptosis ( cis, cis pentadiene system) oxidation through stereo-specific peroxidation to produce corresponding fatty acid hydroperoxides ( ALOX ) genes in humans ( ALOX family can mediate PUFAs peroxidation to generate AA/AdA-PE-OOHs, thereby triggering ferroptosis ( As mentioned above, membranes can be protected from peroxidation damage via a GSH-dependent lipid peroxide repair system
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[DOI] [PubMed] [Google Scholar] 50.He L, Wang L, Wang Z, et al
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