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CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons

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Interestingly, single alanine amino acid substitutions of some interacting residues within the TMD had much larger effects on exendin-4 affinity than removal of the first 8 residues of the peptide, suggesting that peptide ECD and TMD interactions are correlated, such that non-optimal interactions with the TMD likely promote faster peptide dissociation from the ECD

peptide signalling interactions

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