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N Engl J Med 2018;379:62332

3.2 Hypothyroidism and central nervous system dysfunction Hypothyroidism affects the central nervous system in ways that extend beyond metabolic slowing

(Safflower) flower extract attenuates hepatic injury and steatosis in a rat model of type 2 diabetes mellitus via Nrf2-Dependent hypoglycemic, antioxidant, and hypolipidemic effects

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And by day 21, only about 35 percent of the original active compound remains