In fact its a time bomb and there will be guaranteed casualties amongst B12 deficient patients who only take oral tablets during this period
Gulden, M
Dihexa activates the HGF/c-Met pathway, stimulating synaptogenesis (the creation of new connections between neurons)
Activation of the TLR4 complex by DAMPs and LPS, resulting from increased intestinal permeability, initiates a cascade of processes that activate NF-B, ROS/RNS, nitrosylation, IRS, NLRP3, and the creation of oxidation-specific epitopes, culminating in autoimmune responses to oxidation-specific epitopes and nitroso-adducts
this is usually mediated by hijacking the cellular mechanism
Washout periods: for crossover designs, a 7-14 day washout should be adequate given both short serum half-life and the typical decay timeline of tissue-level effects post-dosing