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It also plays an important role in the stress response by modulating inflammatory and oxidative processes

As a Mediterranean port city, Valletta's urban form and architectural heritage, deeply intertwined with its maritime history, reflect a rich tapestry of cultural and historical significance (UNESCO, 2023)

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Two patient cohorts were enrolled: treatment-naive patients with no prior exposure to any interferon formulation or direct-acting antivirals, and treatment-experienced patients who had prior treatment with interferon and/or host-targeted antivirals or direct-acting antivirals other than NS3 or NS5A inhibitors or NS5B thumb-1 inhibitors, which were exclusionary (study protocol appears in Supplement 1)