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musculus : 19733 ( Regucalcin ), 20522 ( SVCT1) , 54338 ( SVCT2 ) and 22626 ( SVCT3 )

Merkel et al

Today, there is still a large number of GLP-1R agonists entering clinical trials, which will lead to a big explosion in the future, so let's wait and see together

Side Effects Comparison# Retatrutide Side Effects# Phase 2 trial data revealed: Gastrointestinal : Nausea (24-46%), diarrhea (16-26%), vomiting (9-20%), constipation (6-16%) Heart rate : Small mean increase (2-4 bpm) potentially related to glucagon receptor activation Injection site reactions : Mild and transient Hepatic : Transient elevations in liver enzymes observed Discontinuation rate : 6-10% due to adverse events in Phase 2 The glucagon receptor component introduces a unique side effect profile compared to GLP-1-only or GIP/GLP-1 dual agonists

Back Gilbert, B, Rosenthal, D (21 Jan 2024) 'The complete history & strategy of Novo Nordisk: Novo Nordisk (Ozempic)', Acquired podcast, Season 14, Episode 1

Differences in these peptides between men could account for different conception results and success with fertility treatments