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Dual GIP/GLP-1 Agonist Dual-action peptide for enhanced metabolic support and glucose regulation

2+ /calmodulin (CaM)-dependent protein kinase kinase/CAM-dependent protein kinase IV/Prolactin regulatory element binding (CaMKK/CaMKIV/PREB), increasing apolipoprotein AI (apo AI) mRNA and promoter expression, and increasing apo AI secretion, thereby mediating intracellular cholesterol efflux

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Despite localization of mGIPR-Ab/P3 predominantly in CVOs, and not in deeper parenchyma of the brain, c-Fos activation was observed in multiple neural substrates involved in food intake control 21,22,23,24,25,26,27,28,29,30 (Fig