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Vitamin C acts synergistically with GSH by regenerating oxidized glutathione (GSSG GSH), maintaining optimal antioxidant levels

Iran J Pharm Res 24(1):e160886

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However, Healthline noted that glutathione levels in the body might be reduced due to poor nutrition, environmental toxins, stress and ageing

Together, these interconnected pathways establish a compartmentalized antioxidant defense architecture that critically determines ferroptosis sensitivity