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A systematic review of 17 clinical studies involving over 25,000 subjects showed that increased systemic TMAO concentrations were correlated with higher cardiovascular events, and the relative risk of all-cause mortality was shown to increase by 7.6% per 10 mol/L increments of plasma TMAO concentration (Schiattarella et al., 2017)

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Also, some side effects may be too rare to detect, or attribute to the drugs, even in clinical trials enrolling thousands of patients

PMID: 29155147

/ Water is necessary for the detoxification processes that glutathione supports