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3 Genetic polymorphisms Genetic variation critically modulates MASLD susceptibility and progression (98, 99)

Monthly during use: Self-examine all moles using the ABCDE criteria: - A symmetry: One half does not match the other - B order: Edges are irregular, ragged, or blurred - C olor: Uneven color with shades of brown, black, red, white, or blue - D iameter: Larger than 6 mm (the size of a pencil eraser) - E volving: Any change in size, shape, color, elevation, or any new symptom (bleeding, itching, crusting) 3

Endocrinology 142 , 11481155 (2001)

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Keep the bottle tightly closed when not in use to prevent contamination

mRNA expression of ER decreased in the adipose tissue of obese women [70], and selective depletion of ER in adipocytes subsequently increased the adipocyte size and total adiposity in both sexes [71]