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These include being women, thyroid disease, menopausal or perimenopausal, and rapid weight loss

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Titrate up only as tolerated

Elevated TREM2, MS4A, CD33, APOE , and TYROBP gene expression were also observed in postmortem ALS spinal cord samples (Jauregui et al., 2023)

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They reduce appetite, slow gastric emptying, increase feelings of fullness and at pharmacological doses produce significant reductions in caloric intake that result in substantial weight loss