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This happens because they can suppress the body's natural release of melatonin, the hormone that signals darkness and sleep to the brain (Stoschitzky et al., 1999) Q5: Can the nicotine patch cause insomnia

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The preclinical evidence is robust, consistent, and mechanistically plausible, but the gap between rat sciatic nerve transection models and human diabetic neuropathy is significant

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This dual effectmedication-driven metabolic shift plus weight-loss-related insulation lossexplains why cold sensitivity often emerges during the first weeks of treatment when weight loss accelerates