That absolute difference is small, but the trial was not designed to detect it
doi: 10.1016/j.isci.2019.05.030 Wu YR, Shi XY, Ma CY, Zhang Y, Xu RX, Li JJ
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Since mitochondrial defects have been broadly observed in many different diseases in which TDP-43 pathology is commonly detected, and because mitochondria are crucially important for maintaining metabolomic homeostasis, one of the key questions that remains unanswered is: What are the metabolomic changes that occur with respect to TDP-43 pathology? We investigated the metabolomic perturbations that occur in the motor cortex of prp-TDP-43 A315T mice, a mouse model which recapitulates many aspects of TDP-43 pathology observed in ALS and ALS/FTLD patients 19
[1] [2] These effects result primarily from the medication's mechanism of slowing gastric motility
Diabetes Care, 44(3), 567-575
