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Int J Obes Suppl 6 , S15S21, (2016)

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Abbreviations SMA: alpha smooth muscle actin AD: Alzheimers disease AI: Artificial intelligence A : Amyloid- Aib: -aminoisobutyric acid AAV: Adeno-associated virus AuNPs: gold NPs APP : Amyloid precursor protein A 142: 42-amino-acid amyloid-beta isoform ALS: Amyotrophic lateral sclerosis Apoe/: Apolipoprotein E knockout Ach: Acetylcholine ANP: Atrial natriuretic peptide APP/PS1 mice: Amyloid precursor protein/presenilin 1 mice ABC: Accelerated blood clearance AMF: Alternating magnetic fields AGILE: AI-guided Ionizable lipid engineering BM-MSCs: Bone marrow-derived mesenchymal stem cells BAT: Brown adipose tissue BACE1: -secretase 1 BV2: Mouse microglial cell line bEnd.3: Mouse brain endothelial cells BSA: Bovine serum albumin CMC: Chemistry, manufacturing, and controls COPD: Chronic obstructive pulmonary disease Col: Collagen CRP: C-reactive protein CtrlNP: Control NP CVD: Cardiovascular diseases Cy5.5: Cyanine 5.5 CXCR4: C-X-C motif chemokine receptor 4 CNS: Central nervous system cryo-EM: cryo-electron microscopy cAMP: cyclic adenosine monophosphate DPP-4: Dipeptidyl peptidase-4 DSPC: 1,2-distearoyl-sn-glycero-3-phosphocholine dPA: dehydro-palmitoylated DN: Diabetic nephropathy DLS: Dynamic light scattering DFO: Deferoxamine DDM: n-dodecyl--D-maltoside DPPC: Dipalmitoylphosphatidylcholine DP: Diabetic periodontitis DMG-PEG: 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol Epac: Exchange protein directly activated by cAMP E