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We have therefore established a link between a metabolic switch in response to GSH loss to the inability to mount antibody-mediated immune responses in vivo

Cell Discov 11:25 Chikara S, Nagaprashantha LD, Singhal J et al (2018) Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment

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Biochemical role: During collagen biosynthesis, specific lysine residues in procollagen chains undergo enzymatic hydroxylation by lysyl hydroxylase (a vitamin C-dependent, iron-requiring enzyme) to form hydroxylysine

Yazaki T., et al

Their narrow, deep structure limits how much any topical or microneedling approach can accomplish