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Kenji Yamada Institution: Kyoto University, Japan Result: MSC-derived exosomes administered intranasally reduced serum cortisol and TNF- levels

Stop usage if irritation starts for 1 week and then begin again with a smaller amount or dilute the product

Store at room temperature or refrigerate for best taste

If the ambient temperature was below 25C and the exposure was a single event (812 hours), the vial is likely still usable for the remainder of its 28-day window

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Concurrently, oxidative stress can trigger NF-KB signaling, upregulating inflammation-related genes and exacerbating ferroptosis (125)