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Conflicts of Interest Industry groups had no role in the design or conduct of this study, in the collection, analysis, or interpretation of data, or in the preparation, review, or approval of this manuscript

A "natural" origin of a substance tells you nothing about overall safety at a synthetic dose, by an unphysiological route, in a manufactured form whose purity is not independently verified

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They are a real, evidence-based tool for clients who have struggled with weight, appetite regulation, metabolic health, and the deeper biology that diet and exercise alone cannot always override