glutathione depletion assay Schematic chemical reaction of the Total (adapted Glutathione Quantification GSSG/GSH Quantification Kit

Franco R, Cidlowski JA

10.1021/acs.molpharmaceut.4c00490 113 KumazoeM.FujimuraY.YoshitomiR.ShimadaY.TachibanaH

Representative tissue specimens were embedded in paraffin, sectioned at 4 m, stained with hematoxylin and eosin (H&E), and evaluated by light microscopy using an Olympus 71 digital camera and an Olympus BX51 microscope (Japan) acquiring digital images saved as uncompressed 24-bit RGB TIFF files

LZ: Writing original draft, Writing review and editing, Conceptualization, Data curation, Formal Analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization

High salt concentrations interfere with copper chelation and can destabilize the peptide complex

Cancer is often seen as a disease of genetic chaos driven by mutations, chromosomal instability, and uncontrolled cellular division